lipM [2017-8-11 16:0:3]

octanoyltransferase

locus: BSU24530

pI: 5.93

mw: 32.09 kDa

protein length: 278 aa

gene length: 834 bp

function: biosynthesis of lipoic acid

product: octanoyltransferase

essential: no

ec: 2.3.1.181

synonyms: yqhM

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.7|Biosynthesis and scavenging of lipoic acid]

Gene

Coordinates: 2,543,968 → 2,544,804

The protein

Catalyzed reaction/ biological activity

• transfers the octanoyl moiety from octanoyl-acyl carrier protein to the lipoyl domains of the 2-oxoacid dehydrogenases via a thioester-linked octanoyl-LipM intermediate [Pubmed|20882995]

Structure

• [PDB|3A7A] (from ''E. coli'', 25% identity) [Pubmed|20089862]

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• genes: [gene|19CEB80CF637F1FED7C493EF743B4BFA632C8D44|lipM]-[gene|FF34DC303E8A7C9FAA205A6C2924961963B14EB1|mntR]
  description: [pubmed|22383849]

Biological materials

Mutant

• MGNA-C469 (yqhM::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2467 NBRP B. subtilis, Japan]

References

Reviews

• 27074917

Original publications

• 20882995,20089862